54 Results for "

Lithospermum officinale L.

" in MedChemExpress (MCE) Product Catalog:
Products (54)

54 Results for "Lithospermum officinale L." in MCE Product Catalog:

14
[6]-Gingerol
[6]-Gingerol
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14 Publications Verification
Referencia número: HY-14615
No. CAS: 23513-14-6
Pureza:  99.68%
Synonyms: (S)-(+)-[6]Gingerol
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Cancer Zingiberaceae

Target:  

AMPK Apoptosis

[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
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13
Shogaol
Shogaol
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13 Cited Publications
Referencia número: HY-14616
No. CAS: 555-66-8
Pureza:  99.63%
Synonyms: [6]-Shogaol; 6-Shogaol
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Cancer Zingiberaceae

Target:  

Autophagy

Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
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8
Zingerone
Zingerone
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8 Cited Publications
Referencia número: HY-14621
No. CAS: 122-48-5
Pureza:  99.79%
Synonyms: Vanillylacetone; Gingerone
Category:  

Zingiber officinale Roscoe Monophenols Ketones, Aldehydes, Acids Metabolic Disease Phenols Plants Disease Research Fields Inflammation/Immunology Zingiberaceae

Target:  

Environmental Pollutants NF-κB

Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells . Zingerone can cross the blood-brain barrier (BBB) .
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5
8-Gingerol
8-Gingerol
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5 Cited Publications
Referencia número: HY-N0447
No. CAS: 23513-08-8
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Inflammation/Immunology Cancer Zingiberaceae

Target:  

TRP Channel Bacterial Apoptosis Autophagy STAT PERK EGFR PI3K Akt mTOR Caspase MMP

8-Gingerol can be found in the rhizome of ginger (Z. officinale) and has oral bioactivity. It activates TRPV1, with an EC50 value of 5.0 µM. 8-Gingerol inhibits COX-2 and also suppresses the growth of H. pylori in vitro. Additionally, 8-Gingerol exhibits anticancer, antioxidant, and anti-inflammatory properties by inhibiting the epidermal growth factor receptor (EGFR) and modulating its downstream STAT3/ERK pathway to suppress the proliferation, migration, and invasion of colorectal cancer cells. 8-Gingerol also exerts immunosuppressive effects by inhibiting oxidative stress, inducing cell cycle arrest, promoting apoptosis, and regulating autophagy. Furthermore, 8-Gingerol has cardioprotective effects. 8-Gingerol is promising for research in the fields of cancer, infection, immunosuppression, and cardiovascular diseases.
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5
[10]-Shogaol
[10]-Shogaol
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5 Cited Publications
Referencia número: HY-N2434
No. CAS: 36752-54-2
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Disease Research Fields Cancer Zingiberaceae

Target:  

COX Interleukin Related NF-κB Parasite

[10]-Shogaol is an orally active antioxidant. [10]-Shogaol can be extracted from ginger (Zingiber officinale). [10]-Shogaol1 inhibits COX-2 with an IC50 value of 7.5 μM. [10]-Shogaol inhibits the production of proinflammatory cytokines (IL-1β, IL-6). [10]-Shogaol inhibits NF-κB phosphorylation. [10]-Shogaol has anti-inflammatory effects. [10]-Shogaol has anticancer effects against Docetaxel (HY-B0011)-resistant prostate cancer. [10]-Shogaol exhibits larvicidal activity against L5 larvae of Angiostrongylus cantonensis .
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3
β,β-Dimethylacrylalkannin
β,β-Dimethylacrylalkannin
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3 Cited Publications
Referencia número: HY-N5112A
No. CAS: 34539-65-6
Synonyms: Arnebin 1
Category:  

Quinones other families Other Diseases Plants Disease Research Fields Naphthalene Quinones Pteris livida Mett.

Target:  

FGFR Necroptosis Apoptosis CDK JNK

β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active FGFR1 inhibitor (IC50=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the CDK1/Cdc25C pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis .
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1
Beta-Acetoxyisovalerylshikonin
Beta-Acetoxyisovalerylshikonin
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1 Cited Publications
Referencia número: HY-N2188
No. CAS: 69091-17-4
Category:  

Plants Boraginaceae Naphthalene Quinones Quinones other families Phenols Polyphenols Disease Research Fields Inflammation/Immunology Arnebia euchroma (Royle) Johnst.

Target:  

HIV

Beta-Acetoxyisovalerylshikonin is a naturally occurring naphthoquinone-type shikonin derivative that is widely distributed in the roots and cell suspension cultures of *Arnebia euchroma*, *Arnebia guttata*, *Onosma hispidum* and *Lithospermum erythrorhizon*. Beta-Acetoxyisovalerylshikonin exhibits favorable antibacterial, anti-inflammatory, wound-healing promoting and antioxidant activities, and also possesses potential anti-tumor and anti-HIV properties .
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1
β,β-Dimethylacrylshikonin
β,β-Dimethylacrylshikonin
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1 Cited Publications
Referencia número: HY-N5112B
No. CAS: 24502-79-2
Synonyms: Isoarnebin I
Category:  

Quinones Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Boraginaceae Naphthalene Quinones Cancer

Target:  

HIF/HIF Prolyl-Hydroxylase Apoptosis Notch NO Synthase Bcl-2 Family

β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth .
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1
[6]-Gingerol (Standard)
[6]-Gingerol (Standard)
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1 Cited Publications
Referencia número: HY-14615R
No. CAS: 23513-14-6
Synonyms: (S)-(+)-[6]Gingerol (Standard)
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Zingiberaceae

Target:  

Reference Standards AMPK Apoptosis

-Gingerol (Standard) is the analytical standard of -Gingerol. This product is intended for research and analytical applications. -Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
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1
Isoviolanthin
Isoviolanthin
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1 Cited Publications
Referencia número: HY-N6896
No. CAS: 40788-84-9
Category:  

other families Flavonoids Flavones Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase

Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .
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1
Diacetoxy-6-gingerdiol
Diacetoxy-6-gingerdiol
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1 Cited Publications
Referencia número: HY-133865
No. CAS: 143615-75-2
Pureza:  98.01%
Category:  

Zingiber officinale Roscoe Monophenols Other Diseases Phenols Plants Disease Research Fields Zingiberaceae

Target:  

Interleukin Related

Diacetoxy-6-gingerdiol is a gingerol isolated with anti-inflammatory and antioxidant effects, which is found in the dichloromethane extract of rhizomes of ginger (Zingiber officinale Roscoe). Diacetoxy-6-gingerdiol protects the extracellular matrix of nucleus pulposus cells and ameliorates intervertebral disc degeneration by inhibiting the IL-1β-mediated NLRP3 pathway .
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1
Shogaol (Standard)
Shogaol (Standard)
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1 Cited Publications
Referencia número: HY-14616R
No. CAS: 555-66-8
Synonyms: [6]-Shogaol (Standard); 6-Shogaol (Standard)
Category:  

Zingiber officinale Roscoe Monophenols Phenols Plants Zingiberaceae

Target:  

Reference Standards Autophagy

Shogaol (Standard) is the analytical standard of Shogaol. This product is intended for research and analytical applications. Shogaol ( -Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
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Guaifenesin
Guaifenesin
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Referencia número: HY-B0264
No. CAS: 93-14-1
Synonyms: Guaiacol glyceryl ether; Guaiphenesin; Glycerol guaiacolate
Category:  

Guaiacum officinale L. Natural Products other families Neurological Disease Zygophyllaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Mucin

Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough .
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Violanthin
Violanthin
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Referencia número: HY-N6895
No. CAS: 40581-17-7
Category:  

Flavones Plants Dendrobium officinale Kimura et Migo other families Flavonoids Orchidaceae Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

Cholinesterase (ChE)

Violanthin is isolated from the stems of Dendrobium officinale, has potent antioxidant and antibacterial activities. Violanthin inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM .
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β-Hydroxyisovalerylshikonin
β-Hydroxyisovalerylshikonin
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Referencia número: HY-N4201
No. CAS: 7415-78-3
Category:  

Quinones Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Disease Research Fields Boraginaceae Naphthalene Quinones Cancer

Target:  

EGFR Src

Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells .
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Isobutylshikonin
Isobutylshikonin
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Referencia número: HY-N2592
No. CAS: 52438-12-7
Category:  

Quinones Phenols Polyphenols Plants Lithospermum canescens Lehm. Disease Research Fields Inflammation/Immunology Boraginaceae Naphthalene Quinones

Target:  

Others

Isobutylshikonin is a kind of shikonin pigments found in hairy root culture of Lithospermum canescens. Isobutylshikonin decreases cell viability induces marked changes in JA-4 cells with nuclear condensation and swelling in the presence of LPS (HY-D1056) .
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(-)-Rabdosiin
(-)-Rabdosiin
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Referencia número: HY-N6880A
No. CAS: 119152-54-4
Category:  

Ketones, Aldehydes, Acids Phenols Polyphenols Plants Symphytum officinale L. Boraginaceae

Target:  

HIV

(-)-Rabdosiin is a novel phenolic marker, found from Symphytum officinale L. (-)-Rabdosiin shows antioxidant, neuroprotective or anti-HIV activities .
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Geranial
Geranial
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Referencia número: HY-W1000105
No. CAS: 141-27-5
Synonyms: (E)-3,7-Dimethylocta-2,6-dienal
Target:  

TNF Receptor Interleukin Related ERK JNK IKK COX NO Synthase Reactive Oxygen Species (ROS)

Áreas de investigación:  

Inflammation/Immunology

Geranial is an aromatic compound. It can be isolated from the fruits of Litsea cubeba Lour and the rhizomes of ginger (Zingiber officinale). Geranial inhibits LPS-induced phosphorylation of ERK1/2, JNK1/3 and IκB in macrophages. It suppresses the secretion of IL-1β, TNF-α and IL-6, as well as the expression of pro-IL-1β, iNOS and COX-2. Geranial increases ROS. It can be used in the research of inflammatory diseases .
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Guaifenesin (Standard)
Guaifenesin (Standard)
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Referencia número: HY-B0264R
No. CAS: 93-14-1
Synonyms: Guaiacol glyceryl ether(Standard); Guaiphenesin(Standard); Glycerol guaiacolate (Standard)
Category:  

Guaiacum officinale L. Natural Products other families Neurological Disease Zygophyllaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

Reference Standards Others

Guaifenesin (Standard) is the analytical standard of Guaifenesin. This product is intended for research and analytical applications. Guaifenesin (Guaiacol glyceryl ether), a constituent of guaiac resin from the wood of Guajacum officinale Linné, is an expectorant. Guaifenesin can alleviate cough discomfortby increasing sputum volume and decreasing its viscosity, thereby promoting effective cough .
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Deoxygeraniol
Deoxygeraniol
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Referencia número: HY-W711045
No. CAS: 2609-23-6
Category:  

Other Monoterpenes Terpenoids Magnoliaceae Oyama sieboldii (K. Koch) N. H. Xia & C. Y. Wu Plants

Target:  

Drug Derivative

Deoxygeraniol, a monoterpenoid, has been reported in Camellia sinensis, Magnolia sieboldii, and Zingiber officinale. It is commonly used as an intermediate in the synthesis of fragrances or flavorings.
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